iD.BRCA
  • Background to BRCA testing in Breast Cancer
  • The rationale for BRCA testing in Breast Cancer
  • Streamlining the BRCA testing process
  • Conducting a germline BRCA test
  • How to interpret BRCA test results
  • Expert opinion on BRCA testing
  • iD.BRCA Ovarian Cancer
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BRCA TESTING FOR WOMEN WITH BREAST CANCER



This website, aimed at healthcare professionals and biomedical scientists, comprises a selection of key elements related to BRCA testing for women with breast cancer. This encompasses why, who, when and how to test



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Intro...

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THE BRCA GENES: WHAT ARE THEY AND WHY ARE THEY IMPORTANT?



The BRCA genes are important tumour suppressors that code for proteins involved in cell regulation and the error-free repair of double-strand DNA breaks



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Testing...


THE RATIONALE FOR BRCA TESTING: CHANGING PARADIGMS



Historically, patients with breast cancer were referred for BRCA testing only for the purpose of assessing disease risk in unaffected family members, who could then consider whether risk reduction such as preventative surgery might be necessary. BRCA testing is also seen as a way to potentially inform the treatment decisions for individuals diagnosed with breast cancer.



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Index...

Clear and concise reporting

The main goal of genetic test reporting is to provide a clear, concise, accurate, fully interpretative and authoritative answer to a clinical question

BRCA mutation prevalence within the breast cancer subpopulations

Breast cancer patients can be categorised into subpopulations by considering the status of their associated HR and HER2 biomarkers

Germline BRCA mutation testing

Germline BRCA testing can be used to identify the risk of breast cancer development in unaffected relatives

The oncogenetic pathway

In the oncogenetic pathway, a referral for a genetics appointment is offered to any patients who are found to carry a BRCA mutation

The classification of variants

Germline BRCA testing can be used to identify the risk of breast cancer development in unaffected relatives

The importance of the multidisciplinary team

The MDT provides access to the range of collaborative professional knowledge and recommendations that is required to help make informed treatment decisions

Background to BRCA testing in Breast Cancer
The rationale for BRCA testing in Breast Cancer
Streamlining the BRCA testing process
Conducting a germline BRCA test
How to interpret BRCA test results
Expert opinion on BRCA testing
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Veeva ID: Z4-17868. Date of preparation: July 2019. Date of expiry: July 2021.
Date of re-review: July 2021.
© AstraZeneca. For non-US, non-UK healthcare professionals only.

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